Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …

Metastasis causes death of 90% of cancer patients, so it is the most significant issue
associated with cancer disease. Thus, it is no surprise that many researchers are trying to …

While actin was discovered in the nucleus over 50 years ago, research lagged for decades
due to strong skepticism. The revitalization of research into nuclear actin occurred after it …

Actin and myosin are major components of the cell cytoskeleton, with structural and
regulatory functions that affect many essential cellular processes. Although they were …

Recent years have provided considerable insights into the dynamic nature of the cell
nucleus, which is constantly reorganizing its genome, controlling its size and shape, as well …

The paradigm states that cytoplasmic actin operates as filaments and nuclear actin is mainly
monomeric, acting as a scaffold in transcription complexes. However, why should a powerful …

Background Nuclear lamins are type V intermediate filament proteins that maintain nuclear
structure and function. Furthermore, Emerin-an interactor of Lamin A/C, facilitates crosstalk …

Highlights•Nuclear actin exists in both monomeric and polymeric forms.•Actin monomers
have been mainly linked to regulation of gene expression.•Polymerized nuclear actin …

Class I histone deacetylases (HDACs) are known to remove acetyl groups from histone tails.
This liberates positive charges on the histone tail and allows for tighter winding of DNA …