The role of natural killer cells in human disease

TL Whiteside, RB Herberman - Clinical immunology and immunopathology, 1989 - Elsevier
Natural killer (NK) cells represent a subset of lymphocytes (up to 15%), distinguishable from
T and B lymphocytes by their morphology, phenotype, and functional capability to …

Natural killer cytotoxicity in the diagnosis of immune dysfunction: criteria for a reproducible assay

TL Whiteside, J Bryant… - Journal of clinical …, 1990 - Wiley Online Library
Current evidence indicates that natural killer (NK) cells, which are large granular
lymphocytes that mediate non‐major histocompatibility complex (MHC)‐restricted …

Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration

Y Wada, O Nakashima, R Kutami, O Yamamoto… - Hepatology, 1998 - journals.lww.com
We examined the clinicopathologic features of 11 surgically resected hepatocellular
carcinomas (HCCs) less than 3 cm in diameter with marked inflammatory cell infiltration …

Natural killer cell activity in patients with hepatocellular carcinoma: a new prognostic indicator after hepatectomy

A Taketomi, M Shimada, K Shirabe, K Kajiyama… - Cancer, 1998 - Wiley Online Library
BACKGROUND Natural cytotoxicity mediated by natural killer (NK) cells is believed to play
an important role in host anticancer defense mechanisms. The aim of this study was to …

Levamisole: known effects on the immune system, clinical results, and future applications to the treatment of cancer.

HC Stevenson, I Green, JM Hamilton… - Journal of clinical …, 1991 - ascopubs.org
Levamisole has been used in a wide array of clinical research and treatment settings over
the past two decades, ranging from such diseases as helminthic infestations to various …

Peripheral blood CD3 and CD4 T-lymphocyte reduction correlates with severity of liver cirrhosis

L Lombardo, A Capaldi, G Poccardi… - International Journal of …, 1995 - Springer
Immunological disturbances with impairment of immune function and a higher incidence of
lymphoproliferative disorders and other malignancies have been described in liver cirrhosis …

Tumor-infiltrating lymphocytes and prognosis of hepatocellular carcinoma

A Kawata, Y Une, M Hosokawa, J Uchino… - Japanese journal of …, 1992 - academic.oup.com
Tumor-infiltrating lymphocytes (TIL) were isolated from 17 human hepatocellular carcinomas
(HCQ. The proliferation of TIL cultured with recombinant interleukin-2 (rlL-2) was evaluated …

Association between insulin‐like growth factor‐2 and metastases after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma: A …

BC Song, YH Chung, JA Kim, HC Lee, HK Yoon… - Cancer, 2001 - Wiley Online Library
BACKGROUND Hypoxia up‐regulates insulin‐like growth factor‐2 (IGF‐2) and thus
stimulates the growth of hepatocellular carcinoma (HCC) cells. In the current study, the …

Natural killer cell activity in patients with hepatocellular carcinoma relative to early development and tumor invasion

WL Chuang, HW Liu, WY Chang - Cancer, 1990 - Wiley Online Library
To evaluate the significance of natural killer (NK) cell activity in the clinical assessment of
patients with hepatocellular carcinoma (HCC), 32 patients combined with liver cirrhosis (LC) …

MRI-monitored transcatheter intra-arterial delivery of SPIO-labeled natural killer cells to hepatocellular carcinoma: preclinical studies in a rodent model

AY Sheu, Z Zhang, RA Omary, AC Larson - Investigative radiology, 2013 - journals.lww.com
Objectives The objective of this study was to test the hypotheses that intra-arterial infusion
allows for targeted natural killer (NK) lymphocyte delivery to hepatocellular carcinoma …