BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and
oxidative stress which may target many organs such as the kidney, retina, and the vascular …

For more than a century, clinicians have attempted to subdivide asthma into different
phenotypes based on triggers that cause asthma attacks, the course of the disease, or the …

Rationale: Reducing asthma exacerbation frequency is an important criterion for approval of
asthma therapies, but the clinical features of exacerbation-prone asthma (EPA) remain …

Despite the use of effective medications to control asthma, severe exacerbations in asthma
are still a major health risk and require urgent action on the part of the patient and physician …

Patients with severe or difficult-to-treat asthma are an understudied population but account
for considerable asthma morbidity, mortality, and costs. The Epidemiology and Natural …

Background Exacerbations represent a major source of morbidity and mortality in asthma
and are a prominent feature of poorly controlled, difficult‐to‐treat disease. Objective The …

Background Asthma attacks are common, serious, and costly. Individual factors associated
with attacks, such as poor symptom control, are not robust predictors. Objective We …

Although assessment of asthma control is important to guide treatment, it is difficult since the
temporal pattern and risk of exacerbations are often unpredictable. In this Review, we …

Background Preventing exacerbations of asthma is a major goal in current guidelines. We
aimed to develop a prediction model enabling practitioners to identify patients at risk of …

Background Asthma attacks are common and have significant physical, psychological, and
financial consequences. Improving the assessment of a child's risk of subsequent asthma …