Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …

Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …

2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American
College of Cardiology Foundation/American Heart Association Task Force on Practice …

It is important that the medical profession play a significant role in critically evaluating the
use of diagnostic procedures and therapies as they are introduced and tested in the …

Heart failure (HF) is a major and growing public health problem in the United States.
Approximately 5 million patients in this country have HF, and over 550 000 patients are …

It is a major goal of clinical pharmacology to understand the dose-effect relationship in
therapeutics. Much progress towards this goal has been made in the last 2 decades through …

The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites.
Renal drug transporters, which are primarily located in the renal proximal tubules, play an …

Many orally administered drugs must overcome several barriers before reaching their target
site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic …

Popular among students and clinicians for its easy-to-read, case-study format, Winter's Basic
Clinical Pharmacokinetics, 7th Edition, clarifies complex concepts to help you confidently …

An important goal in clinical pharmacology is the quantitative prediction of drug effects in
man. Extensive studies in vitro have led to the development and testing of theories relating …