For half a century, it has been known that some patients experience neurocognitive
dysfunction after cardiac surgery; however, defining its incidence, course, and causes …

Anesthetic agents disrupt neurodevelopment in animal models, but evidence in humans is
mixed. The morphologic and behavioral changes observed across many species predicted …

Background In laboratory animals, exposure to most general anaesthetics leads to
neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition …

Background Few studies of how exposure of children to anesthesia may affect
neurodevelopment employ comprehensive neuropsychological assessments. This study …

Background Postoperative cognitive dysfunction (POCD) is a very common complication that
might increase the morbidity and mortality of elderly patients after surgery. However, the …

Paediatric pain and its assessment and management are challenging for medical
professionals, especially in an urgent care environment. Patients in a paediatric emergency …

Background Sevoflurane anesthesia induces Tau phosphorylation and cognitive impairment
in neonatal but not in adult mice. This study tested the hypothesis that differences in brain …

General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

Blood–brain barrier (BBB) dysfunction, eg, increase in BBB permeability, has been reported
to contribute to cognitive impairment. However, the effects of anesthesia and surgery on BBB …

The mechanisms that confer cognitive resilience to Alzheimer's Disease (AD) are not fully
understood. Here, we describe a neural circuit mechanism underlying this resilience in a …