Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

Natural products have proven their value as drugs that can be therapeutically beneficial in
the treatment of various diseases. However, most natural products have low solubility and …

Breast cancer (BC) is one of the most prevalent malignancies and the major contributor to
cancer mortality in women globally, with a high degree of heterogeneity and a dismal …

Four monoterpenoid indole alkaloid dimers (MIADs), axidimins AD (1–4), which possesses
unprecedented apidosperma-aspidosperma-type skeletons, along with twelve known MIAs …

Histone deacetylases (HDACs), a class of enzymes responsible for the removal of acetyl
functional groups from the lysine residues in the amino-terminal tails of core histones, play a …

An organoselenium-catalyzed C2, 3-diarylation of unprotected N–H indoles with electron-
rich aromatics has been developed. This one-pot multicomponent tandem cross …

Aspidosperma and uleine alkaloids belong to the large family of monoterpene indole
alkaloids with diverse biological activities and thus have attracted extensive synthetic …

Indole alkaloids, predominantly found in plants, are a large group of natural product-derived
compounds characterized by a remarkable chemical diversity associated with significant …

Isatis indigotica Fort., belongs to the Brassicaceae family and its leaf is an important Chinese
traditional folklore medicine. After many years of research, phytochemical investigations on it …

Medicinal plants play a huge role in the treatment of various diseases in the Limpopo
province (South Africa). Traditionally, concoctions used for treating tuberculosis and cancer …