Machine learning has shown utility in detecting patterns within large, unstructured, and
complex datasets. One of the promising applications of machine learning is in precision …

The gut microbiota has been linked with chronic diseases such as obesity in humans.
However, the demonstration of causality between constituents of the microbiota and specific …

We draw on genetics research to argue that complex psychological phenomena are most
likely determined by a multitude of causes and that any individual cause is likely to have …

Genome-wide association studies (GWASs) are a valuable tool for understanding the
biology of complex human traits and diseases, but associated variants rarely point directly to …

SNPs discovered by genome-wide association studies (GWASs) account for only a small
fraction of the genetic variation of complex traits in human populations. Where is the …

Despite great progress in identifying genetic variants that influence human disease, most
inherited risk remains unexplained. A more complete understanding requires genome-wide …

In this study, we investigated the effect of five feature selection approaches on the
performance of a mixed model (G-BLUP) and a Bayesian (Bayes C) prediction method. We …

Using variants from the 1000 Genomes Project pilot European CEU dataset and data from
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …

Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …