[HTML][HTML] Immune-mediated inflammatory disease therapeutics: past, present and future
IB McInnes, EM Gravallese - Nature Reviews Immunology, 2021 - nature.com
Immune-mediated inflammatory diseases are common and clinically diverse. Although they
are currently incurable, the therapeutic armamentarium for immune-mediated inflammatory …
are currently incurable, the therapeutic armamentarium for immune-mediated inflammatory …
[HTML][HTML] Deep generative molecular design reshapes drug discovery
Recent advances and accomplishments of artificial intelligence (AI) and deep generative
models have established their usefulness in medicinal applications, especially in drug …
models have established their usefulness in medicinal applications, especially in drug …
[HTML][HTML] A critical overview of computational approaches employed for COVID-19 drug discovery
COVID-19 has resulted in huge numbers of infections and deaths worldwide and brought
the most severe disruptions to societies and economies since the Great Depression …
the most severe disruptions to societies and economies since the Great Depression …
[HTML][HTML] The drug repurposing for COVID-19 clinical trials provide very effective therapeutic combinations: lessons learned from major clinical studies
SARS-CoV-2 has spread across the globe in no time. In the beginning, people suffered due
to the absence of efficacious drugs required to treat severely ill patients. Nevertheless, still …
to the absence of efficacious drugs required to treat severely ill patients. Nevertheless, still …
SARS-CoV-2 antiviral therapy
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …
vaccination, as well as for those who do not respond robustly to vaccination. This review …
[HTML][HTML] Niclosamide for Covid-19: bridging the gap
Aim/purpose Niclosamide (NCL) is an anthelminthic drug, which is widely used to treat
various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL …
various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL …
Synthetic peptides that antagonize the angiotensin-converting enzyme-2 (ACE-2) interaction with SARS-CoV-2 receptor binding spike protein
A Sadremomtaz, ZM Al-Dahmani… - Journal of medicinal …, 2021 - ACS Publications
The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on
host cells to initiate molecular events, resulting in intracellular release of the viral genome …
host cells to initiate molecular events, resulting in intracellular release of the viral genome …
A review on computer‐aided chemogenomics and drug repositioning for rational COVID‐19 drug discovery
S Maghsoudi, B Taghavi Shahraki… - Chemical Biology & …, 2022 - Wiley Online Library
Application of materials capable of energy harvesting to increase the efficiency and
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …
[HTML][HTML] Natural products for the prevention and control of the COVID-19 pandemic: sustainable bioresources
Background: The world has been unprecedentedly hit by a global pandemic which broke the
record of deadly pandemics that faced humanity ever since its existence. Even kids are well …
record of deadly pandemics that faced humanity ever since its existence. Even kids are well …
[HTML][HTML] In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) requires treatments with rapid clinical translatability. Here we develop a multi-target …
CoV-2) requires treatments with rapid clinical translatability. Here we develop a multi-target …