Publisher Summary This chapter discusses the rationale for developing sporozoite vaccines.
Sporozoites are the infective stages of the parasite found in the salivary glands of female …

Physiological processes are regulated to a large extent by physical and chemical
interactions between polypeptides. Although many small molecules have been discovered …

Peptides that are antigenic for T lymphocytes are ligands for two receptors, the class I or II
glycoproteins that are encoded by genes in the major histocompatibility complex, and the …

Highly reiterated repetitive domains occur within the protein antigens of many parasitic taxa,
including Plasmodium, Trypanosoma, Leishmania and Toxoplasma. In malaria it has been …

The α and β subunits of the γ-aminobutyric acidA (GABAA) receptor were expressed
individually in Xenopus oocytes by injection of RNA synthesized from their cloned DNAs …

Publisher Summary This chapter focuses on those forms of genetic diversity that are clearly
understood at the deoxyribonucleic acid (DNA) level. The application of recombinant DNA …

Introduction A safe and effective vaccine will likely be necessary for the control or
eradication of malaria which kills 400,000 annually. Our most advanced vaccine candidate …

T cell clones obtained from a human volunteer immunized with Plasmodium falciparum
sporozoites specifically recognized the native circumsporozoite (CS) antigen expressed on …

Synthetic peptide antigen analogues of native peptide antigens with partial or complete
retro, inverso or retro-inverso modifications are provided. When administered as an …

Current vaccine development strategies for malaria depend on widespread immunological
responsiveness to candidate antigens such as the zygote surface antigens and the …