Despite evidence that ACE inhibitors can improve the prognosis of patients with heart
failure, mortality remains high even when symptoms are mild. The SOLVD studies have …

Left ventricular remodeling is a dynamic process that occurs in reaction to an insult to the
myocardium. The response to either loss of cells, as may occur following myocardial …

We examined the dose-related effects of angiotensin-converting enzyme inhibitors on
circulating and tissue levels of angiotensin and bradykinin peptides by administering …

Background The aim of the present study was to assess the short-and long-term effects of
multiple doses of the angiotensin II receptor antagonist losartan in heart failure. Methods …

Background—Chronic exercise (EX) improves the quality of life and increases the survival of
patients with chronic heart failure (CHF). Because sympathetic nerve activity is elevated in …

BACKGROUND The vasodilatory response to intra-arterial administration of acetylcholine is
reduced in patients with congestive heart failure compared with that of normal subjects. The …

Background KII ACE, the enzyme that converts angiotensin I and inactivates bradykinin, is
highly concentrated in the lungs; its blockade reduces exposure to angiotensin II and …

Objectives. This study was undertaken to investigate the role of endothelium-derived nitric
oxide in the regulation of forearm blood flow during exercise in normal subjects and patients …

NSAIDs are known to attenuate the effects of some antihypertensive medications. It is not
known whether the new class of angiotensin II receptor antagonists is similarly affected. We …

Background—Coprescription of aspirin and ACE inhibitors is frequent in heart failure caused
by coronary artery disease. Negative interaction between aspirin and enalapril has been …