Immune responses in leishmaniasis: an overview

AC Costa-da-Silva, DO Nascimento… - Tropical medicine and …, 2022 - mdpi.com
Leishmaniasis is a parasitic, widespread, and neglected disease that affects more than 90
countries in the world. More than 20 Leishmania species cause different forms of …

From infection to death: an overview of the pathogenesis of Visceral Leishmaniasis

CHN Costa, KP Chang, DL Costa, FVM Cunha - Pathogens, 2023 - mdpi.com
Kala-azar, also known as visceral leishmaniasis (VL), is a disease caused by Leishmania
infantum and L. donovani. Patients experience symptoms such as fever, weight loss …

The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?

JL Casanova, L Abel - Human genetics, 2020 - Springer
Multicellular eukaryotes emerged late in evolution from an ocean of viruses, bacteria,
archaea, and unicellular eukaryotes. These macroorganisms are exposed to and infected by …

[HTML][HTML] Vaccine value profile for leishmaniasis

PM Kaye, G Matlashewski, S Mohan, E Le Rutte… - vaccine, 2023 - Elsevier
Leishmania infections are global, occurring in 98 countries and all World Health
Organization (WHO) regions with 600 million to 1 billion people at risk of infection. Visceral …

A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations

A Sanchez-Mazas - Swiss medical weekly, 2020 - smw.ch
Human leucocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) lying
in the HLA region are known to be associated with several infectious diseases among which …

Overcoming roadblocks in the development of vaccines for leishmaniasis

PM Kaye, S Mohan, C Mantel, M Malhame… - Expert Review of …, 2021 - Taylor & Francis
Introduction The leishmaniases represent a group of parasitic diseases caused by infection
with one of several species of Leishmania parasites. Disease presentation varies because …

Immunotherapy in treatment of leishmaniasis

M Akbari, A Oryan, G Hatam - Immunology Letters, 2021 - Elsevier
Leishmaniasis caused by various species of protozoan transmitted by sand fly vectors
occurs as a spectrum of clinical features including cutaneous, mucocutaneous and visceral …

Vaccines against leishmaniasis: using controlled human infection models to accelerate development

V Parkash, PM Kaye, AM Layton… - Expert Review of …, 2021 - Taylor & Francis
Introduction Leishmaniasis is a neglected tropical disease that is defined by the World
Health Organization as vaccine preventable. Although several new candidate vaccines are …

A Genome-wide Association Study Identifies SERPINB10, CRLF3, STX7, LAMP3, IFNG-AS1, and KRT80 As Risk Loci Contributing to Cutaneous Leishmaniasis in …

LC Castellucci, L Almeida, S Cherlin… - Clinical Infectious …, 2021 - academic.oup.com
Background Our goal was to identify genetic risk factors for cutaneous leishmaniasis (CL)
caused by Leishmania braziliensis. Methods Genotyping 2066 CL cases and 2046 controls …

Identification of vaccine targets & design of vaccine against SARS-CoV-2 coronavirus using computational and deep learning-based approaches

BA Abbasi, D Saraf, T Sharma, R Sinha, S Singh… - PeerJ, 2022 - peerj.com
An unusual pneumonia infection, named COVID-19, was reported on December 2019 in
China. It was reported to be caused by a novel coronavirus which has infected …