The complexity of tobacco smoke leads to some confusion about the mechanisms by which
it causes lung cancer. Among the multiple components of tobacco smoke, 20 carcinogens …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental carcinogens and
metabolized by a variety of xenobiotic-metabolizing enzymes such as cytochrome P450 …

Cancers of the colon are most common in the Western world. In majority of these cases,
there is no familial history and sporadic gene damage seems to play an important role in the …

Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …

Background This study explores and characterizes cell cycle alterations induced by urban
PM2. 5 in the human epithelial cell line BEAS-2B, and elucidates possible mechanisms …

Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …

Aryl hydrocarbon receptor (AhR) is an important transcriptional regulator of drug
metabolizing enzymes that dominantly controls the expression of cytochrome P450 CYP1 …

The aryl hydrocarbon receptor (AHR) is not essential to survival, but does act as a key
regulator of many normal physiological events. The role of this receptor in toxicological …

The formation of more polar and toxic polycyclic aromatic hydrocarbon (PAH) transformation
products is one of the concerns associated with the bioremediation of PAH-contaminated …