Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Abstract Apolipoprotein E (apoE), a 34 kDa glycoprotein, mediates hepatic and extrahepatic
uptake of plasma lipoproteins and cholesterol efflux from lipid-laden macrophages. In …

Apolipoprotein E (APOE) is a component of lipoprotein particles that function in the
homeostasis of cholesterol and other lipids. Although APOE is genetically associated with …

Rationale: Bilateral sonication with focused ultrasound (FUS) in conjunction with
microbubbles has been shown to separately reduce amyloid plaques and …

Background Cerebral glucose hypometabolism is consistently observed in individuals with
Alzheimer's disease (AD), as well as in young cognitively normal carriers of the Ε4 allele of …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

Background Neuropsychiatric systemic lupus erythematosus (NPSLE), with various
morbidities and multiple manifestations in the central nervous system, remains a limited …

Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and
lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic …