Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality,
underscores the urgent need for enhanced insights into the molecular and cellular …

The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Accumulating research suggests that the tumor immune microenvironment (TIME) plays an
essential role in regulation of tumor growth and metastasis. The cellular and molecular …

Specificity remains a major challenge to current therapeutic strategies for cancer. Mutation
associated neoantigens (MANAs) are products of genetic alterations, making them highly …

KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various
human cancers and implicated in poor survival. The G-quadruplex formed in KRAS …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

Lung cancer is the leading cause of cancer-related death worldwide. KRAS mutations are
the most common oncogenic alterations found in lung cancer. Unfortunately, treating KRAS …

The administration of many cancer drugs is tailored to genetic tests. Some genomic events,
eg, alterations of EGFR or BRAF oncogenes, result in the conformational change of the …