Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of
cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid …

Cancer is the term used to describe over 100 diseases that share several common
hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the …

Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-
calorie diet have been recognized as major risk factors for the most common types of cancer …

The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring
the accumulation of multiple genetic alterations, influenced by a patient's genetic …

Metastasis entails numerous biological functions that collectively enable cancerous cells
from a primary site to disseminate and overtake distant organs. Using genetic and …

Colorectal cancer is the third common cancer in this world, accounting for more than 1
million cases each year. However, detailed etiology and mechanism of colorectal cancer …

Background & Aims: Chronic inflammation is a risk factor for colon cancer in patients with
ulcerative colitis (UC). The molecular mechanisms linking inflammation and colon …

Although consumption of fruits, vegetables, spices, cereals and pulses has been associated
with lower incidence of cancer and other chronic diseases, how these dietary agents and …

Abstract Cyclooxygenase-1 and-2 (COX-1/2) catalyze the initial step in the formation of
prostaglandins. Very recently their role in carcinogenesis has become more evident. They …