Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSA
P Andersen, MA Nielsen, M Resende, TS Rask… - PLoS …, 2008 - journals.plos.org
Pregnancy-associated malaria is caused by Plasmodium falciparum malaria parasites
binding specifically to chondroitin sulfate A in the placenta. This sequestration of parasites is …
binding specifically to chondroitin sulfate A in the placenta. This sequestration of parasites is …
Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1
Members of the Plasmodium falciparum Erythrocyte Membrane protein 1 (PfEMP1) family
expressed on the surface of malaria-infected erythrocytes mediate binding of the parasite to …
expressed on the surface of malaria-infected erythrocytes mediate binding of the parasite to …
Immunisation with Recombinant PfEMP1 Domains Elicits Functional Rosette-Inhibiting and Phagocytosis-Inducing Antibodies to Plasmodium falciparum
Background Rosetting is a Plasmodium falciparum virulence factor implicated in the
pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P …
pathogenesis of life-threatening malaria. Rosetting occurs when parasite–derived P …
An In Vivo and In Vitro Model of Plasmodium falciparum Rosetting and Autoagglutination Mediated by varO, a Group A var Gene Encoding a Frequent Serotype
I Vigan-Womas, M Guillotte, C Le Scanf… - Infection and …, 2008 - Am Soc Microbiol
In the Saimiri sciureus monkey, erythrocytes infected with the varO antigenic variant of the
Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting) …
Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting) …
Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
A Chêne, S Gangnard, C Dechavanne, S Dechavanne… - NPJ vaccines, 2018 - nature.com
Over 50 million women are exposed to the risk of malaria during pregnancy every year.
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
C Pehrson, L Mathiesen, KK Heno, A Salanti… - Malaria journal, 2016 - Springer
Background Placental malaria occurs when Plasmodium falciparum infected erythrocytes
sequester in the placenta. Placental parasite isolates bind to chondroitin sulphate A (CSA) …
sequester in the placenta. Placental parasite isolates bind to chondroitin sulphate A (CSA) …
Effects of sex, parity, and sequence variation on seroreactivity to candidate pregnancy malaria vaccine antigens
AV Oleinikov, E Rossnagle, S Francis… - The Journal of …, 2007 - academic.oup.com
Background. Plasmodium falciparum-infected erythrocytes adhere to chondroitin sulfate A
(CSA) to sequester in the human placenta, and pregnancy malaria (PM) is associated with …
(CSA) to sequester in the human placenta, and pregnancy malaria (PM) is associated with …
Evaluation of the Antigenic Diversity of Placenta-Binding Plasmodium falciparum Variants and the Antibody Repertoire among Pregnant Women
M Hommel, SR Elliott, V Soma, G Kelly… - Infection and …, 2010 - Am Soc Microbiol
Pregnant women are infected by specific variants of Plasmodium falciparum that adhere and
accumulate in the placenta. Using serological and molecular approaches, we assessed the …
accumulate in the placenta. Using serological and molecular approaches, we assessed the …
Structure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions
S Gangnard, A Lewit-Bentley, S Dechavanne… - Scientific reports, 2015 - nature.com
The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …
clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive …
Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates
M Avril, MJ Hathaway, A Srivastava, S Dechavanne… - PloS one, 2011 - journals.plos.org
The high molecular weight, multidomain VAR2CSA protein mediating adhesion of
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …
Plasmodium falciparum-infected erythrocytes in the placenta is the leading candidate for a …