[HTML][HTML] The role of mitochondrial dysfunction in atrial fibrillation: translation to druggable target and biomarker discovery

L Pool, LFJM Wijdeveld, NMS de Groot… - International journal of …, 2021 - mdpi.com
Atrial fibrillation (AF) is the most prevalent and progressive cardiac arrhythmia worldwide
and is associated with serious complications such as heart failure and ischemic stroke …

[HTML][HTML] NADPH oxidases and oxidative stress in the pathogenesis of atrial fibrillation

R Ramos-Mondragón, A Lozhkin, AE Vendrov… - Antioxidants, 2023 - mdpi.com
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence
increases with age. The irregular and rapid contraction of the atria can lead to ineffective …

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy …

F Seibertz, T Rubio, R Springer, F Popp… - Cardiovascular …, 2023 - academic.oup.com
Aims Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology
alterations which promote AF chronification and treatment resistance. Development of novel …

Genetic and non-genetic risk factors associated with atrial fibrillation

LJ Young, S Antwi-Boasiako, J Ferrall, LE Wold… - Life sciences, 2022 - Elsevier
Atrial fibrillation (AF) is the most common arrhythmic disorder and its prevalence in the
United States is projected to increase to more than twelve million cases in 2030. AF …

[HTML][HTML] Mitochondrial dysfunction in atrial fibrillation—Mechanisms and pharmacological interventions

P Muszyński, TA Bonda - Journal of Clinical Medicine, 2021 - mdpi.com
Despite the enormous progress in the treatment of atrial fibrillation, mainly with the use of
invasive techniques, many questions remain unanswered regarding the pathomechanism of …

Oxidative stress: a bystander or a causal contributor to atrial remodelling and fibrillation?

D Dobrev, SC Dudley Jr - Cardiovascular Research, 2021 - academic.oup.com
This editorial refers to 'Inducibility, but not stability, of atrial fibrillation is increased by NOX2
overexpression in mice', by AS Mighiu et al., pp. 2354–2364. Despite enormous research …

Regions of highly recurrent electrogram morphology with low cycle length reflect substrate for atrial fibrillation

S Yoo, M Rottmann, J Ng, D Johnson, B Shanab… - Basic to Translational …, 2023 - jacc.org
Traditional anatomically guided ablation and attempts to perform electrogram-guided atrial
fibrillation (AF) ablation (CFAE, DF, and FIRM) have not been shown to be sufficient …

[HTML][HTML] LncRNA GAS5 Attenuates Cardiac Electrical Remodeling Induced by Rapid Pacing via the miR-27a-3p/HOXa10 Pathway

S Xi, H Wang, J Chen, T Gan, L Zhao - International Journal of Molecular …, 2023 - mdpi.com
Previous studies indicated long non-coding RNAs (lncRNAs) participated in the
pathogenesis of atrial fibrillation (AF). However, little is known about the role of lncRNAs in …

[HTML][HTML] Research on atrial fibrillation mechanisms and prediction of therapeutic prospects: focus on the autonomic nervous system upstream pathways

J Huang, B Wu, P Qin, Y Cheng, Z Zhang… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) is the most common clinical arrhythmia disorder. It can easily lead to
complications such as thromboembolism, palpitations, dizziness, angina, heart failure, and …

Nicotinamide adenosine dinucleotide phosphate oxidase-mediated signaling in cardiac remodeling

A Visnagri, RR Oexner… - Antioxidants & redox …, 2023 - liebertpub.com
Significance: Reactive oxygen species (ROS) play a key role in the pathogenesis of cardiac
remodeling and the subsequent progression to heart failure (HF). Nicotinamide adenosine …