During the past 40 years, cytokines and cytokine receptors have been extensively
investigated as either cancer targets or cancer treatments. A strong preclinical rationale …

Immune cell infiltration into solid tumors, their movement within the tumor microenvironment
(TME), and interaction with other immune cells are controlled by their directed migration …

Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-
methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein …

Glioblastoma (GBM) is the most aggressive primary malignant brain cancer and urgently
requires effective treatments. Chimeric antigen receptor T (CAR-T) cell therapy offers a …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Tumor cells constantly interact with the surrounding microenvironment. Increasing evidence
indicates that targeting the tumor microenvironment could complement traditional treatment …

Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …

Platelets play significant and varied roles in cancer progression, as detailed throughout this
review series, via direct interactions with cancer cells and by long-range indirect interactions …

Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis
and resistance to chemo-and radiotherapy, ultimately leading to tumor relapse. As a …