Abstract Chemokine receptor-4 (CXCR4) has been reported to be overexpressed in
glioblastoma (GBM) and to be associated with poor survival. This study investigated the …

Simple Summary Beyond its pre-eminent role in the context of tumor cell growth as well as
metastasis, the CXC motif chemokine receptor 4 (CXCR4) is a key player in the …

To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients
identified in multiple databases, we proposed that late relapses result from steady stochastic …

In many solid tumors, cancer stem cells (CSC) represent a population with tumor-initiating,
self-renewal, and differentiation potential, which can be identified by surface protein …

Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as
CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical …

Obesity has a noteworthy role in breast tumor initiation and progression. Among the
mechanisms proposed, the most validated is the development of chronic low-grade …

Dominant, although nonexclusive roles of CXCR4 and its chief ligand CXCL12 in bone
marrow (BM) retention and preservation of the relative quiescence of hematopoietic …

Despite histological evidence in various solid tumor entities, available experience with
CXCR4-directed diagnostics and endoradiotherapy mainly focuses on hematologic …

Chemokine receptor CXCR4 is a key factor for tumor growth and metastasis in several types
of human cancer. This study investigated the feasibility of CXCR4-directed imaging of small …

Pancreatic cancer (PaCa) has the highest death rate and incidence is increasing. Poor
prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor …