In health, the near-eucapnic, highly efficient hyperpnea during mild-to-moderate intensity
exercise is driven by three obligatory contributions, namely, feedforward central command …

In chronic obstructive pulmonary disease (COPD), the progressive loss of lung tissue is
widely considered irreversible. Thus, various treatment and rehabilitation schemes …

Rationale: Cardiopulmonary exercise testing (CPET) is the gold standard to evaluate
exertional breathlessness, a common and disabling symptom. However, the interpretation of …

Key points Patients with mild chronic obstructive pulmonary disease (COPD) have an
elevated ventilatory equivalent to CO2 production (/) during exercise, secondary to …

The pulmonary circulation is a low-pressure, low-resistance circuit whose primary function is
to deliver deoxygenated blood to, and oxygenated blood from, the pulmonary capillary bed …

The majority of smokers with chronic obstructive pulmonary disease (COPD) have mild
airflow limitation as determined by simple spirometry. Although small airway dysfunction is …

Background and objective The combination of both reduced resting diffusing capacity of the
lung for carbon monoxide (DLCO) and ventilatory efficiency (increased ventilatory …

DLCO/NO, the combined single‐breath measurement of the diffusing capacity to carbon
monoxide (DLCO) and nitric oxide (DLNO) measured either during exercise or in the resting …

Background The purpose of this study was to determine if altered central chemoreceptor
characteristics contributed to the elevated ventilation relative to carbon dioxide production …

Exertional dyspnea, a key complaint of patients with chronic obstructive pulmonary disease
(COPD), ultimately reflects an increased inspiratory neural drive to breathe. In non …