Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Cardiovascular diseases and specifically heart failure (HF) impact global health and impose
a significant economic burden on society. Despite current advances in standard of care, the …

Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the
spaces between cardiomyocytes following both acute and chronic tissue damage events …

Background Excessive myocardial fibrosis is the pathological basis of heart failure following
myocardial infarction (MI). Although calycosin improves cardiac function, its effect on cardiac …

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases regulate production of
reactive oxygen species (ROS) that cause oxidative damage to cellular components but also …

Keloid disorder, a group of fibroproliferative skin disorders, is clinically comprised of keloids,
hypertrophic scars, keloidalis nuchae, and acne keloidalis. The prototype of these disorders …

BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts
differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation …

Myocardial fibrosis is the villain of sudden cardiac death. Myocardial ischemia/reperfusion
(MI/R) injury induces cardiomyocyte damage or even death, which in turn stimulates …

Cardiovascular diseases (CVDs) present a major social problem worldwide due to their high
incidence and mortality rate. Many pathophysiological mechanisms are involved in CVDs …

Heart failure (HF) with preserved ejection fraction (HFpEF) is defined as HF with an ejection
fraction (EF)≥ 50% and elevated cardiac diastolic filling pressures. The underlying causes …