Physiologic alterations are frequently evident in critically ill patients. These alterations can
significantly affect the pharmacokinetics of drugs used in this patient population …

In recent years, there has been a substantial increase in opioid use and abuse, and in
opioid-related fatal overdoses. The increase in opioid use has resulted at least in part from …

Developmental and physiological changes in children contribute to variation in drug
disposition with age. Additionally, critically ill children suffer from various life-threatening …

The complexity of managing critically ill patients has increased since the early establishment
of intensive care units in the 1950s. Despite of the fact that the number of drugs available to …

Objective: To determine whether indocyanine green (ICG) and glucose dilutions can detect
generalized capillary protein leakage in septic patients without requiring repeated …

Potential overestimation of plasma volume (PV) determination by the conventional
indocyanine green (ICG) dilution method (PV-ICG) can occur when generalized capillary …

Objectives: To determine whether the initial distribution volume of glucose (IDVG) rather
than plasma volume or blood volume is correlated better with cardiac output during the 4 …

Introduction: Monitoring of circulating blood volume is important in the management of
critically ill patients. Current methods of circulating blood volume measurements such as …

IMPLICATIONS: Routine cardiovascular variables immediately after major surgery cannot
predict the subsequent hypovolemic hypotension produced by the shift of the extracellular …

Objective: To determine whether plasma volume determined by the indocyanine green (ICG)
dilution method (PV-ICG) is equally accurate independently of its disappearance rate from …