Cellular signal transduction by anandamide and 2-arachidonoylglycerol

AC Howlett, S Mukhopadhyay - Chemistry and physics of lipids, 2000 - Elsevier
Anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol mediate many of their
actions via either CB1 or CB2 cannabinoid receptor subtypes. These agonist-receptor …

Endocannabinoids control the induction of cerebellar LTD

PK Safo, WG Regehr - Neuron, 2005 - cell.com
The long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a
central role in motor learning. Endocannabinoid release and LTD induction both depend …

2-Arachidonoylglycerol and the cannabinoid receptors

T Sugiura, K Waku - Chemistry and physics of lipids, 2000 - Elsevier
2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated
from rat brain and canine gut as an endogenous cannabinoid receptor ligand (Sugiura, T …

[HTML][HTML] The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications

B Horváth, P Mukhopadhyay, G Haskó… - The American journal of …, 2012 - Elsevier
Oxidative stress and inflammation play critical roles in the development of diabetes and its
complications. Recent studies provided compelling evidence that the newly discovered lipid …

The fatty acid amide hydrolase (FAAH)

DG Deutsch, N Ueda, S Yamamoto - Prostaglandins, Leukotrienes and …, 2002 - Elsevier
The fatty acid amide hydrolase (FAAH), is the enzyme responsible for the hydrolysis of
anandamide, an endocannabinoid. The FAAH knockout, the assays for FAAH, the activity of …

Endothelium‐dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?

TM Griffith - British journal of pharmacology, 2004 - Wiley Online Library
An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology

A Giuffrida, M Beltramo, D Piomelli - Journal of Pharmacology and …, 2001 - ASPET
The endocannabinoids, a family of endogenous lipids that activate cannabinoid receptors,
are released from cells in a stimulus-dependent manner by cleavage of membrane lipid …

Aberrant cannabinoid signaling impairs oviductal transport of embryos

H Wang, Y Guo, D Wang, PJ Kingsley, LJ Marnett… - Nature medicine, 2004 - nature.com
Ectopic pregnancy is a major reproductive health issue. Although other underlying causes
remain largely unknown, one cause of ectopic pregnancy is embryo retention in the fallopian …

The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling

J Tam, V Trembovler, V Di Marzo… - The FASEB …, 2008 - Wiley Online Library
We have recently reported that in bone the cannabinoid CB1 receptor is present in
sympathetic terminals. Here we show that traumatic brain injury (TBI), which in humans …

Nephrotoxic effects of common and emerging drugs of abuse

WF Pendergraft III, LC Herlitz… - Clinical journal of the …, 2014 - journals.lww.com
The kidneys can be injured in diverse ways by many drugs, both legal and illegal. Novel
associations and descriptions of nephrotoxic effects of common and emerging drugs of …