Background Colorectal cancer (CRC) is one of the leading cause of cancer deaths
worldwide. Since CRC is largely asymptomatic until alarm features develop to advanced …

This article describes changes in the basic digestive functions (motility, secretion,
intraluminal digestion, absorption) that occur during aging. Elderly individuals frequently …

Background Removal of adenomas reduces colorectal cancer incidence and mortality;
however, the benefit of surveillance colonoscopy on colorectal cancer risk remains unclear …

With increasing age, the incidence of both benign and malignant gastrointestinal (GI)
disease rises. Endoscopic procedures are commonly performed in elderly and very elderly …

Importance The risks and benefits of surveillance colonoscopy in elderly patients have not
been well characterized. Objective To investigate the relative impact of surveillance …

Importance National guidelines balance risks and benefits of population-level cancer
screening among adults with average risk. Older adults are not recommended to receive …

Colorectal cancer has a great socio-sanitary relevance. It represents the third cancer by
incidence and mortality. Ageing plays a major role in the development of colorectal cancer …

Importance Most clinical practice guidelines recommend stopping cancer screenings when
risks exceed benefits, yet low-value screenings persist. The Veterans Health Administration …

Methods We collected data regarding clinical features by directly interviewing patients and
obtaining histopathological data from hospital records. Patients aged less than 50 years …

Background RAC3 coactivator overexpression has been implicated in tumorigenesis,
contributing to inhibition of apoptosis and autophagy. Both mechanisms are involved in …