β3-Adrenoceptors in the cardiovascular system: putative roles in human pathologies

B Rozec, C Gauthier - Pharmacology & therapeutics, 2006 - Elsevier
The sympathetic nervous system is central for the neurohumoral regulation of the
cardiovascular system and is largely involved in many cardiovascular diseases affecting …

Experimental evidences of nitric oxide‐dependent vasodilatory activity of nebivolol, a third‐generation β‐blocker

L Ignarro - Blood Pressure, 2004 - Taylor & Francis
Nebivolol is a new and selective β 1‐adrenergic receptor antagonist whose haemodynamic
profile is different from that of classical β‐blockers. The blood pressure lowering effects of …

Third-generation β-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action

L Kalinowski, LW Dobrucki, M Szczepanska-Konkel… - Circulation, 2003 - Am Heart Assoc
Background—Nebivolol and carvedilol are third-generation β-adrenoreceptor antagonists,
which unlike classic β-blockers, have additional endothelium-dependent vasodilating …

Endothelial β3-Adrenoreceptors Mediate Nitric Oxide–Dependent Vasorelaxation of Coronary Microvessels in Response to the Third-Generation β-Blocker Nebivolol

C Dessy, J Saliez, P Ghisdal, G Daneau, II Lobysheva… - Circulation, 2005 - Am Heart Assoc
Background—The therapeutic effects of nonspecific β-blockers are limited by
vasoconstriction, thus justifying the interest in molecules with ancillary vasodilating …

Vasodilating β-adrenoceptor blockers as cardiovascular therapeutics

N Toda - Pharmacology & therapeutics, 2003 - Elsevier
β-Adrenoceptor blocking agents (β-blockers) have been established as therapeutics for
treatment of patients with hypertension, ischemic heart diseases, chronic heart failure …

Nebivolol, a Vasodilating Selective β1-Blocker, Is a β3-Adrenoceptor Agonist in the Nonfailing Transplanted Human Heart

B Rozec, M Erfanian, K Laurent, JN Trochu… - Journal of the American …, 2009 - jacc.org
Objectives: The present study was to assess whether nebivolol could activate β3-adrenergic
receptors (ARs) in the human heart. Background: Nebivolol is a third-generation β-blocker …

Nitric oxide mechanisms of nebivolol

A Maffei, G Lembo - Therapeutic advances in cardiovascular …, 2009 - journals.sagepub.com
β-blockers are among the most widely used drugs in the prevention and treatment of
cardiovascular disease, although they are associated with increased peripheral resistance …

Different pharmacological properties of two enantiomers in a unique β‐blocker, nebivolol

LJ Ignarro - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol is a racemic combination of d‐nebivolol (+ SRRR nebivolol) and l‐nebivolol (–
RSSS nebivolol) that differs chemically from other β‐blockers, with an absolutely …

[HTML][HTML] The β-blocker nebivolol is a GRK/β-arrestin biased agonist

CE Erickson, R Gul, CP Blessing, J Nguyen, T Liu… - PloS one, 2013 - journals.plos.org
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes
vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol …

Nebivolol: Pharmacologic Profile of an Ultraselective, Vasodilatory β1‐Blocker

LM Prisant - The Journal of Clinical Pharmacology, 2008 - Wiley Online Library
Beta‐blockers are well‐established therapeutic agents in the treatment of hypertension and
cardiovascular disease. However, these agents are highly heterogeneous. Beta‐blockers …