The multifaceted role of aquaporin-9 in health and its potential as a clinical biomarker
IV da Silva, S Garra, G Calamita, G Soveral - Biomolecules, 2022 - mdpi.com
Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox
homeostasis, with proven involvement in a variety of pathophysiological conditions such as …
homeostasis, with proven involvement in a variety of pathophysiological conditions such as …
Inhibitors of NLRP3 inflammasome in ischemic heart disease: focus on functional and redox aspects
P Pagliaro, C Penna - Antioxidants, 2023 - mdpi.com
Myocardial ischemia-reperfusion injury (MIRI) is caused by several mechanisms, including
the production of reactive oxygen species (ROS), altered cellular osmolarity, and …
the production of reactive oxygen species (ROS), altered cellular osmolarity, and …
Carvacrol protects mice against LPS-induced sepsis and attenuates inflammatory response in macrophages by modulating the ERK1/2 pathway
C Yan, W Kuang, L Jin, R Wang, L Niu, C Xie, J Ding… - Scientific Reports, 2023 - nature.com
Macrophages play an important role in the development of life-threatening sepsis, which is
characterized by multiorgan dysfunction, through their ability to produce inflammatory …
characterized by multiorgan dysfunction, through their ability to produce inflammatory …
AQP3 and AQP9—Contrary Players in Sepsis?
P Thon, T Rahmel, D Ziehe, L Palmowski… - International Journal of …, 2024 - mdpi.com
Sepsis involves an immunological systemic response to a microbial pathogenic insult,
leading to a cascade of interconnected biochemical, cellular, and organ–organ interaction …
leading to a cascade of interconnected biochemical, cellular, and organ–organ interaction …
Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in db/db Mice
M Florio, A Engfors, P Gena, J Larsson, A Massaro… - Cells, 2022 - mdpi.com
Aquaporin-9 (AQP9) is a facilitator of glycerol and other small neutral solute transmembrane
diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult …
diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult …
Platelet P2Y12 signalling pathway in the dysregulated immune response during sepsis
Sepsis is a complicated pathological condition in response to severe infection. It is
characterized by a strong systemic inflammatory response, where multiple components of …
characterized by a strong systemic inflammatory response, where multiple components of …
Aquaporin Expression and Regulation in Clinical and Experimental Sepsis
NS Lotsios, C Keskinidou, I Dimopoulou… - International Journal of …, 2023 - mdpi.com
Sepsis is an inflammatory disorder caused by the host's dysfunctional response to infection.
Septic patients present diverse clinical characteristics, and in the recent years, it has been …
Septic patients present diverse clinical characteristics, and in the recent years, it has been …
Sex-related differences in the response of anti-platelet drug therapies targeting purinergic signaling pathways in sepsis
Sepsis, a complex clinical syndrome resulting from a serious infection, is a major healthcare
problem associated with high mortality. Sex-related differences in the immune response to …
problem associated with high mortality. Sex-related differences in the immune response to …
Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure
C Verra, S Mohammad, GF Alves, E Porchietto… - Frontiers in …, 2023 - frontiersin.org
Sepsis is one of the major complications of surgery resulting in high morbidity and mortality,
but there are no specific therapies for sepsis-induced organ dysfunction. Data obtained …
but there are no specific therapies for sepsis-induced organ dysfunction. Data obtained …
Advances in Aquaporins
G Calamita - Cells, 2023 - mdpi.com
Aquaporins (AQPs) are a family of transmembrane channel proteins, widespread throughout
nature, where they facilitate the diffusion of water and small solutes into and out of both cells …
nature, where they facilitate the diffusion of water and small solutes into and out of both cells …