Recent research using multicellular tumor spheroids has resulted in new insights in the
regulation of invasion and metastasis, angiogenesis and cell cycle kinetics. The onset and …

Spheroids are three-dimensional cell aggregates expressing histotypic organisation in vitro
comparable to tissue continuity in vivo. They can be prepared from normal tissue and from …

This book presents the fundamental physics of optical interferometry as applied to
biophysical, biological and medical research. Interference is at the core of many types of …

Holographic optical coherence imaging is a full-frame variant of coherence-domain imaging.
An optoelectronic semiconductor holographic film functions as a coherence filter placed …

It has recently been established that the microenvironment plays a major role in many
physiological and pathological events. Indeed cell–cell and cell–extracellular matrix …

Holographic optical coherence imaging is an en face form of optical coherence tomography
that uses low-coherence digital holography as a coherence gate to select light from a …

A large body of evidence indicates that three dimensional (3D) cancer models are superior
to two-dimensional (2D) ones in better representing the in vivo phenomena. Indeed, 3D …

Tissue dynamics spectroscopy combines dynamic light scattering with short-coherence
digital holography to capture intracellular motion inside multicellular tumor spheroid tissue …

A system for motility contrast imaging a biological target within tissue comprising a CCD
array; an illumination source for generating an incoming beam; a first beam splitter for …

The effects of cell density on cell interaction are reviewed and different types of organotypic
culture described and distinguished from organ culture. Organ culture uses …