Objective To compare the risk for all cause and overdose mortality in people with opioid
dependence during and after substitution treatment with methadone or buprenorphine and …

Background Retention in opioid substitution (OST) treatment is associated with substantial
reductions in all cause and overdose mortality. This systematic review aims to identify both …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Background Alcohol and drug use can have negative consequences on the health,
economy, productivity, and social aspects of communities. We aimed to use data from the …

Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

Opioid use disorder (OUD) is associated with a high risk of premature death. Medication-
assisted treatment (MAT) is the primary treatment for opioid dependence. We …

Amid worsening opioid overdose death rates, the nation continues to face a persistent
addiction treatment gap limiting access to quality care for opioid use disorder (OUD). Three …

A meta‐review, or review of systematic reviews, was conducted to explore the risks of all‐
cause and suicide mortality in major mental disorders. A systematic search generated 407 …

Executive summary Inspired by unprecedented improvements in human health and
development in recent decades, our world has embarked on a quest that only a generation …

North America is experiencing an unprecedented overdose crisis driven by the proliferation
of fentanyl and its analogues in the illicit drug supply. In 2018 there were 67,367 drug …