Low back pain is a major cause of disability worldwide that declines the quality of life; it
poses a substantial economic burden for the patient and society. Intervertebral disc (IVD) …

Inflammation is a natural host defense mechanism that protects the body from pathogenic
microorganisms. A growing body of research suggests that inflammation is a key factor in …

Objective To explore the effects of acute paraquat (PQ) exposure on the phenotypic
polarization of hippocampal microglia and its mechanism. Methods An acute PQ exposure …

Inflammatory pain is the perception of noxious stimuli that occurs during inflammation or an
immune response. Glial cells are widespread in the central and peripheral nervous systems …

Ethnopharmacological relevance Scutellaria baicalensis (SB) is a traditional Chinese
medicine (TCM). In the clinical application of TCM, SB has been divided into two …

Respiratory syncytial virus (RSV) pneumonia is the main cause of acute bronchiolitis in
infants. Luteolin-7-O-glucoside (LUT-7G) is a natural flavonoid, which exists in a variety of …

Chikungunya Virus (CHIKV) is having a major impact on humans with potentially life-
threatening and debilitating arthritis. The lack of a specific antiviral drug against the CHIKV …

Intervertebral disc degeneration (IDD) is one of the main causes of low back pain (LBP),
which severely reduces the quality of life and imposes a heavy financial burden on the …

Regulating macrophage-hepatic stellate cells (HSCs) crosstalk through SIRT1-TLR2/TLR4
has contributed to the essence of new pharmacologic strategies to improve hepatic fibrosis …

Transcriptomics of dry age-related macular degeneration (AMD) patients with premature
aging revealed the upregulated pathways involved in glycerolipid metabolism, tyrosine …