Highly processed foods can be considered addictive substances based on established scientific criteria

AN Gearhardt, AG DiFeliceantonio - Addiction, 2023 - Wiley Online Library
Background There is growing evidence that an addictive‐eating phenotype may exist. There
is significant debate regarding whether highly processed foods (HPFs; foods with refined …

Dopamine circuit mechanisms of addiction-like behaviors

CL Poisson, L Engel, BT Saunders - Frontiers in Neural Circuits, 2021 - frontiersin.org
Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Novelty-induced locomotor behavior predicts heroin addiction vulnerability in male, but not female, rats

BN Kuhn, N Cannella, AD Crow, AT Roberts… - …, 2022 - Springer
Rationale The ongoing rise in opioid use disorder (OUD) has made it imperative to better
model the individual variation within the human population that contributes to OUD …

Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats

K Ishiwari, CP King, CD Martin, JA Tripi, AM George… - Scientific Reports, 2024 - nature.com
Organisms must regulate their behavior flexibly in the face of environmental challenges.
Failure can lead to a host of maladaptive behavioral traits associated with a range of …

Genome-wide association study on three behaviors tested in an open field in heterogeneous stock rats identifies multiple loci implicated in psychiatric disorders

MH Gunturkun, T Wang, AS Chitre… - Frontiers in …, 2022 - frontiersin.org
Many personality traits are influenced by genetic factors. Rodents models provide an
efficient system for analyzing genetic contribution to these traits. Using 1,246 adolescent …

Effects of two kinds of noradrenergic ADHD medicines on sign-tracking and goal-tracking in male rats.

JM Holden - Experimental and Clinical Psychopharmacology, 2022 - psycnet.apa.org
Sign-and goal-tracking are behaviors seen in many species when a conditioned stimulus
and it's corresponding unconditioned stimulus are presented at separate locations, and …

Effects of bupropion on sign-and goal-tracking in male Sprague Dawley rats

JM Holden - Behavioural Brain Research, 2023 - Elsevier
Relapse into addiction is often triggered by cues that have a Pavlovian association with
drugs and drug-taking. Sign-tracking involves approach of and interaction with Pavlovian …

Dextromethorphan reduces sign-tracking but not goal-tracking in male Sprague-Dawley rats

JM Holden, A Salem - Neurobiology of Learning and Memory, 2022 - Elsevier
Sign-tracking is a well-known phenomenon in appetitive Pavlovian conditioning in which
subjects approach the site of a conditioned stimulus (CS) associated with an appetitive …

Effects of three serotonin reuptake inhibitors on sign-tracking in male Sprague-Dawley rats

JM Holden - Physiology & Behavior, 2023 - Elsevier
Sign-tracking is a behavior with relevance to cue-triggered relapse addiction, a Pavlovian
conditioned approach behavior directed at the conditioned stimulus. The study examined …

Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats

JM Holden, A Barbaro, K Azure, M Arth - Pharmacology Biochemistry and …, 2024 - Elsevier
Sign-tracking is a Pavlovian conditioned approach behavior thought to be important in
understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may …