Rheumatoid arthritis progression mediated by activated synovial fibroblasts

E Neumann, S Lefèvre, B Zimmermann, S Gay… - Trends in molecular …, 2010 - cell.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial
hyperplasia and progressive joint destruction. Rheumatoid arthritis synovial fibroblasts …

Treating rheumatoid arthritis to target: physician and patient adherence issues in contemporary rheumatoid arthritis therapy

N Wabe, MD Wiese - Journal of evaluation in clinical practice, 2017 - Wiley Online Library
Abstract Development of the treat‐to‐target (T2T) strategy, the process whereby drug
therapy is adjusted until the therapeutic goal is achieved, has revolutionized how …

The value of rheumatoid factor and anti-citrullinated protein antibodies as predictors of response to infliximab in rheumatoid arthritis: an exploratory study

R Klaasen, T Cantaert, CA Wijbrandts, C Teitsma… - …, 2011 - academic.oup.com
Objective. It remains unclear whether autoantibodies are useful biomarkers to tailor the
choice of biological treatment in RA. We investigated the relationship between the presence …

Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo

Z Zainal, AA Rahim, AK Radhakrishnan, SK Chang… - Scientific reports, 2019 - nature.com
The tocotrienol-rich fraction (TRF) from palm oil contains vitamin E, which possesses potent
antioxidant and anti-inflammatory activities. Rheumatoid arthritis (RA) is a chronic joint …

Longitudinal model‐based meta‐analysis in rheumatoid arthritis: an application toward model‐based drug development

I Demin, B Hamrén, O Luttringer… - Clinical Pharmacology …, 2012 - Wiley Online Library
level longitudinal data on the clinical efficacy of drugs for rheumatoid arthritis (RA) are
available in the literature. This information can be used to optimize the clinical development …

Biologics—beyond the joints

Z Szekanecz, S Szántó, Z Szabó, A Váncsa… - Autoimmunity …, 2010 - Elsevier
Biologics including tumor necrosis factor α (TNF-α), interleukin-6 receptor (IL-6R), T and B
cell inhibitors are very effective therapeutic agents for the treatment of arthritides. These …

Costs associated with rheumatoid arthritis in Italy: past, present, and future

M Benucci, V Rogai, F Atzeni, V Hammen… - ClinicoEconomics …, 2016 - Taylor & Francis
This literature review examines available evidence on the current and past costs associated
with rheumatoid arthritis (RA) in Italy, together with the future health-economic prospects for …

IL-17A/IL-17RA interaction blockade sensitizes synovial macrophages to efferocytosis and PD-L1 signaling via rewiring STAT-3/ADAM17/MERTK axis in rheumatoid …

S Samarpita, S Srivastava, M Srikanth, AM Jose… - International …, 2024 - Elsevier
Defective clearance of apoptotic cells due to impaired efferocytosis sustains error in self-
tolerance that exacerbates rheumatoid arthritis (RA). However, the molecular determinant …

Optimizing outcomes in rheumatoid arthritis patients with inadequate responses to disease-modifying anti-rheumatic drugs

K Pavelka, AF Kavanaugh, A Rubbert-Roth… - …, 2012 - academic.oup.com
Conventional DMARDs such as MTX are the mainstay of treatment for patients with RA.
However, failure to achieve adequate disease control in many patients, even with …

Low Percentage of Signal Regulatory Protein α/β+ Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid …

L Magill, M Adriani, V Berthou, K Chen… - Frontiers in …, 2018 - frontiersin.org
An important goal for personalized treatment is predicting response to a particular
therapeutic. A drawback of biological treatment is immunogenicity and the development of …