Introduction: WHO recommends tenofovir, efavirenz, and lamivudine or emtricitabine for first-
line antiretroviral therapy (ART) in adults, which replaced more toxic regimens using …

Depression negatively impacts mood, behavior, and mental and physical health. It is the
third leading cause of suicides worldwide and leads to decreased quality of life. We …

Introduction: Several antiretroviral drugs used to treat infection with the human
immunodeficiency virus (HIV) are substrates of enzymes belonging to the cytochrome P450 …

Objectives The main aim of this study was to investigate the effect of CYP2B6 gene
polymorphisms on efavirenz (EFV) plasma concentrations in Han Chinese patients with …

Efavirenz is mainly metabolized by cytochrome P450 2B6 (CYP2B6). This study aimed to
examine the frequencies of CYP2B6 and the association between CYP2B6 polymorphisms …

Background Tuberculosis (TB) is the leading opportunistic infection of people living with
human immunodeficiency virus (HIV; PLWH). Cytochrome P450 (CYP) 2B6 and ATP …

Pharmacogenetics refers to the effect of single nucleotide polymorphisms (SNPs) within
human genes on drug therapy outcome. Its study might help clinicians to increase the …

Clinical data on the relationships of cytochrome P450 (CYP2) B6 516G> T polymorphisms
with efavirenz-induced central nervous system (CNS) side effects and virological response …

Abstract Background The cytochrome P450 CYP2B6* 6 (CYP2B6 c. 516G> T; rs3745274) is
one of the genetic factors that alters the drug metabolism in antimalarial, antiretroviral and …

Antiretroviral therapy has dramatically improved the survival rate of perinatally HIV-infected
children. For them to thrive, it is necessary to understand better their mental health issues …