The epigenome coordinates spatial-temporal specific gene expression during development
and in adulthood, for the maintenance of homeostasis and upon tissue repair. The upheaval …

Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding RNAs
(ncRNAs) produced by the specific cleavage of precursor or mature tRNAs. tsRNAs are …

Despite the advancements, cancer has remained one of the appalling diseases, with
numerous casualties due to delayed prognosis and poor survival rate. To this end …

The cumulative number of stem cell divisions in a tissue, known as mitotic age, is thought to
be a major determinant of cancer-risk. Somatic mutational and DNA methylation (DNAm) …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Being aware of the need to develop more efficient therapies against cancer, herein we
disclose an innovative approach for the design of selective antiproliferative agents. We have …

Mutations in the p53 gene compromise its role as guardian of genomic integrity, yielding
predominantly missense p53 mutant proteins. The gain-of-function hypothesis has long …

Aging and cancer exhibit apparent links that we will examine in this review. The null
hypothesis that aging and cancer coincide because both are driven by time, irrespective of …

Hollow silica spheres have been widely studied for drug delivery because of their excellent
biosecurity and high porosity. However, difficulties with degradation in the tumor …

In recent years, cancer immunotherapy has undergone a transformative shift toward
personalized and targeted therapeutic strategies. Bacteria‐derived outer membrane …