Recent progresses in exosome-based systems for targeted drug delivery to the brain

S Bashyal, C Thapa, S Lee - Journal of Controlled Release, 2022 - Elsevier
Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

[HTML][HTML] Engineering exosome-based biomimetic nanovehicles for wound healing

A Joorabloo, T Liu - Journal of Controlled Release, 2023 - Elsevier
Complexity and difficulties in wound management are pressing concerns that affect patients'
quality of life and may result in tissue infection, necrosis, and loss of local and systemic …

[HTML][HTML] Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease

M Sheykhhasan, R Amini, SS Asl, M Saidijam… - Biomedicine & …, 2022 - Elsevier
Alzheimer's disease (AD) is a degenerative disease that causes memory and learning
impairments as well as dementia. Coenzyme Q10 (CoQ10) is an anti-inflammatory and anti …

Nanotherapeutic and stem cell therapeutic strategies in neurodegenerative diseases: A promising therapeutic approach

M Wei, Z Yang, S Li, W Le - International journal of nanomedicine, 2023 - Taylor & Francis
Neurodegeneration is characterized by progressive, disabling, and incurable neurological
disorders with the massive loss of specific neurons. As one of the most promising potential …

Alternating magnetic field-promoted nanoparticle mixing: the on-chip immunocapture of serum neuronal exosomes for Parkinson's disease diagnostics

M Sharafeldin, S Yan, C Jiang, GK Tofaris… - Analytical …, 2023 - ACS Publications
The analysis of cargo proteins in exosome subpopulations has considerable value in
diagnostics but a translatable impact has been limited by lengthy or complex exosome …

[HTML][HTML] Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic …

F Natale, S Fusco, C Grassi - Translational Neurodegeneration, 2022 - Springer
Neurodegenerative disorders are one of the most common causes of disability and
represent 6.3% of the global burden of disease. Among them, Alzheimer's, Parkinson's, and …

[HTML][HTML] Extracellular vesicles in neurodegenerative diseases: A systematic review

A Raghav, M Singh, GB Jeong, R Giri… - Frontiers in molecular …, 2022 - frontiersin.org
Introduction Extracellular vesicles (EVs) are known to have a significant role in the central
nervous system (CNS) and neurodegenerative disease. Methods PubMed, Scopus, ISI Web …

Exosome‐Mediated miR‐21 Was Involved in the Promotion of Structural and Functional Recovery Effect Produced by Electroacupuncture in Sciatic Nerve Injury

Y Liu, Y Yang, F Mou, J Zhu, H Li… - Oxidative medicine …, 2022 - Wiley Online Library
Purpose. Our study is aimed at investigating the mechanism by which electroacupuncture
(EA) promoted nerve regeneration by regulating the release of exosomes and exosome …

Exosomes of mesenchymal stem cells as a proper vehicle for transfecting miR‐145 into the breast cancer cell line and its effect on metastasis

M Sheykhhasan, N Kalhor… - BioMed Research …, 2021 - Wiley Online Library
Background. Despite recent advances in scientific knowledge and clinical practice,
management, and treatment of breast cancer, as one of the leading causes of female …

[HTML][HTML] Small extracellular vesicles' miRNAs: biomarkers and therapeutics for neurodegenerative diseases

WQ Lim, KH Michelle Luk, KY Lee, N Nurul, SJ Loh… - Pharmaceutics, 2023 - mdpi.com
Neurodegenerative diseases are critical in the healthcare system as patients suffer from
progressive diseases despite currently available drug management. Indeed, the growing …