Several syndromes manifest as recurrent daily fevers, skin lesions, and multisystem
inflammation. We describe 4 patients with early-onset recurrent fevers, annular violaceous …

Leukemia cutis is an extramedullary manifestation of leukemia. The frequency and age
distribution depend on the leukemia subtype. The clinical and morphological findings have a …

Extramedullary (EM) manifestations of acute leukemia include a wide variety of clinically
significant phenomena that often pose therapeutic dilemmas. Myeloid sarcoma (MS) and …

Extracellular matrix stiffness influences biological functions of some tumors. However, it
remains unclear how cancer subtypes with different oncogenic mutations respond to matrix …

Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …

Chronic myelomonocytic leukemia (CMML) is a rare clonal hematopoietic disorder that can
also involve the skin. The histopathology of these skin lesions is not clearly defined, and few …

Background Genomic landscape of extramedullary acute myeloid leukemia (EM‐AML),
including myeloid sarcoma (MS) and leukemia cutis (LC), is not well characterized. The …

Vascular endothelial cells are a critical component of the hematopoietic microenvironment
that regulates blood cell production. Recent studies suggest the existence of functional cross …

Importance Leukemia cutis (LC) is an important yet understudied extramedullary
manifestation of leukemia. Previous reports have suggested poor prognosis for patients with …

The role of the vascular microenvironment is increasingly studied in acute myeloid
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …