Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

S Akhter, MSI Arman, MA Tayab… - Critical Reviews in …, 2022 - Taylor & Francis
Abstract Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …

Sweeteners and the Gut Microbiome: Effects on Gastrointestinal Cancers

RK Al-Ishaq, P Kubatka, D Büsselberg - Nutrients, 2023 - mdpi.com
Worldwide, the demand for natural and synthetic sweeteners in the food industry as an
alternative to refined sugar is increasing. This has prompted more research to be conducted …

Neohesperidin dihydrochalcone ameliorates high-fat diet-induced glycolipid metabolism disorder in rats

Y Xiao, D Su, X Hu, G Yang, Y Shan - Journal of Agricultural and …, 2022 - ACS Publications
High-fat diet (HFD) is closely related to the formation of metabolic diseases. Studies have
confirmed that neohesperidin dihydrochalcone (NHDC) possesses the biological activity of …

Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN …

X Zhang, J Liu, Y Sun, Q Zhou, X Ding… - Pharmaceutical …, 2023 - Taylor & Francis
Context Gouty arthritis (GA) is a characteristically inflammatory disease often associated with
lipid metabolism disorder. Huangqin Qingrechubi capsule (HQC) has been used for the …

Vitamin D3 affects browning of white adipocytes by regulating autophagy via PI3K/Akt/mTOR/p53 signaling in vitro and in vivo

Y Zhao, R Qin - Apoptosis, 2022 - Springer
Promoting brown fat-like phenotype in white adipose tissue has been a promising strategy
for the treatment of obesity. Vitamin D3 (VD3) has been indicated to affect differentiation of …

Regiospecific hydrogenation of bromochalcone by unconventional yeast strains

M Łużny, D Kaczanowska, B Gawdzik, A Wzorek… - Molecules, 2022 - mdpi.com
This research aimed to select yeast strains capable of the biotransformation of selected 2′-
hydroxybromochalcones. Small-scale biotransformations were carried out using four …

Dietary Apigenin Relieves Body Weight and Glycolipid Metabolic Disturbance via Pro‐Browning of White Adipose Mediated by Autophagy Inhibition

S Xiong, S Yu, K Wang, X Xiong, M Xia… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Apigenin (AP) has many pharmacological activities, including anti‐inflammation,
hyperlipidemia‐lowering, and so on. Previous studies show that AP can reduce lipid …

A combination of rebaudioside A and neohesperidin dihydrochalcone suppressed weight gain by regulating visceral fat and hepatic lipid metabolism in ob/ob mice

Y Kim, H Han, Y Oh, H Shin, G Park, S Park… - Food Science and …, 2024 - Springer
Abstract Rebaudioside A (Reb A) and neohesperidin dihydrochalcone (NHDC) are known
as intense sweeteners. This study aimed to examine the anti-obesity effects of Reb A and …

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

H Ohtsuka, T Shimasaki, H Aiba - Advanced Biology, 2024 - Wiley Online Library
Yeast is an excellent model organism for research for regulating aging and lifespan, and the
studies have made many contributions to date, including identifying various factors and …

Naringin, neohesperidin and their corresponding dihydrochalcones as bioactive substances: a symphony of bitter–sweet

R Wang, W You, H Lin, Y Cao, C Xu… - Food Quality and …, 2023 - academic.oup.com
Bitter is generally undesirable, although it is an important part of flavor. Bitter substances
exhibit diverse health-promoting activities, which is in line with the famous Chinese saying 'a …