mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
Modifications in an emergency: the role of N1-methylpseudouridine in COVID-19 vaccines
The novel coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, has inspired
one of the most efficient vaccine development campaigns in human history. A key aspect of …
one of the most efficient vaccine development campaigns in human history. A key aspect of …
Role of nanotechnology behind the success of mRNA vaccines for COVID-19
A Khurana, P Allawadhi, I Khurana, S Allwadhi… - Nano Today, 2021 - Elsevier
The emergency use authorization (EUA) by the US-FDA for two mRNA-based vaccines
BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) has brought hope of addressing …
BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) has brought hope of addressing …
Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …
A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
Lipid nanoparticle (LNP)-formulated mRNA vaccines were rapidly developed and deployed
in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying …
in response to the SARS-CoV-2 pandemic. Due to the labile nature of mRNA, identifying …
Lipid nanoparticles in the development of mRNA vaccines for COVID-19
Abstract Coronavirus disease (COVID-19) was first reported in December 2019, Hubei
Province, China. As on 9th December 2021, severe acute respiratory syndrome-coronavirus …
Province, China. As on 9th December 2021, severe acute respiratory syndrome-coronavirus …
Delivery strategies for mRNA vaccines
S Ramachandran, SR Satapathy, T Dutta - Pharmaceutical medicine, 2022 - Springer
The therapeutic potential for messenger RNA (mRNA) in infectious diseases and cancer
was first realized almost three decades ago, but only in 2018 did the first lipid nanoparticle …
was first realized almost three decades ago, but only in 2018 did the first lipid nanoparticle …
mRNA vaccines for cancer immunotherapy
YL Vishweshwaraiah, NV Dokholyan - Frontiers in immunology, 2022 - frontiersin.org
Immunotherapy has emerged as a breakthrough strategy in cancer treatment. mRNA
vaccines are an attractive and powerful immunotherapeutic platform against cancer because …
vaccines are an attractive and powerful immunotherapeutic platform against cancer because …
The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …