Crucial for mRNA-based vaccines are the composition, structure, and properties of lipid
nanoparticles (LNPs) as their delivery vehicle. Using all-atom molecular dynamics …

In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

Lipid nanoparticles (LNPs), composed of ionized lipids, helper lipids, and cholesterol,
provide general therapeutic effects by facilitating intracellular transport and avoiding …

Abstract Currently, messenger RNA (mRNA)-based lipid nanoparticle formulations
revolutionize the clinical field. Cationic polymer-based complexes (polyplexes) represent an …

RNA technology has recently come to the forefront of innovative medicines and is being
explored for a wide range of therapies, including prophylactic and therapeutic vaccines …

Oral cavity carcinomas are the most frequent malignancies among head and neck
malignancies. Oral tumors include not only oral cancer cells with different potency and …

In recent years, the use of messenger RNA (mRNA) in the fields of gene therapy,
immunotherapy, and stem cell biomedicine has received extensive attention. With the …

Innate immunity is the first line of defense against invading pathogens. Innate immune cells
can recognize invading pathogens through recognizing pathogen-associated molecular …

Nonviral nanoparticles have emerged as an attractive alternative to viral vectors for gene
therapy applications, utilizing a range of lipid‐based, polymeric, and inorganic materials …

Immunotherapy is revolutionizing the clinical management of patients with different cancer
types by sensitizing autologous or allogenic immune cells to the tumor microenvironment …