Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
[HTML][HTML] The insulin receptor: an important target for the development of novel medicines and pesticides
X Zhang, X Zhu, X Bi, J Huang, L Zhou - International journal of molecular …, 2022 - mdpi.com
The insulin receptor (IR) is a transmembrane protein that is activated by ligands in insulin
signaling pathways. The IR has been considered as a novel therapeutic target for clinical …
signaling pathways. The IR has been considered as a novel therapeutic target for clinical …
SPRTN patient variants cause global-genome DNA-protein crosslink repair defects
P Weickert, HY Li, MJ Götz, S Dürauer… - Nature …, 2023 - nature.com
DNA-protein crosslinks (DPCs) are pervasive DNA lesions that are induced by reactive
metabolites and various chemotherapeutic agents. Here, we develop a technique for the …
metabolites and various chemotherapeutic agents. Here, we develop a technique for the …
Structural basis for activation of DNMT1
A Kikuchi, H Onoda, K Yamaguchi, S Kori… - Nature …, 2022 - nature.com
DNMT1 is an essential enzyme that maintains genomic DNA methylation, and its function is
regulated by mechanisms that are not yet fully understood. Here, we report the cryo-EM …
regulated by mechanisms that are not yet fully understood. Here, we report the cryo-EM …
Domain structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA methyltransferases
In mammals, three major DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …
Mechanistic basis for maintenance of CHG DNA methylation in plants
DNA methylation is an evolutionarily conserved epigenetic mechanism essential for
transposon silencing and heterochromatin assembly. In plants, DNA methylation widely …
transposon silencing and heterochromatin assembly. In plants, DNA methylation widely …
Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns
S Adam, J Bräcker, V Klingel, B Osteresch… - Communications …, 2022 - nature.com
Abstract TET dioxygenases convert 5-methylcytosine (5mC) preferentially in a CpG context
into 5-hydroxymethylcytosine (5hmC) and higher oxidized forms, thereby initiating DNA …
into 5-hydroxymethylcytosine (5hmC) and higher oxidized forms, thereby initiating DNA …
Selective chemical tracking of Dnmt1 catalytic activity in live cells
V Stankevičius, P Gibas, B Masiulionytė, L Gasiulė… - Molecular cell, 2022 - cell.com
Enzymatic methylation of cytosine to 5-methylcytosine in DNA is a fundamental epigenetic
mechanism involved in mammalian development and disease. DNA methylation is brought …
mechanism involved in mammalian development and disease. DNA methylation is brought …
DNMT1 inhibition by pUG-fold quadruplex RNA
LI Jansson-Fritzberg, CI Sousa, MJ Smallegan… - RNA, 2023 - rnajournal.cshlp.org
Aberrant DNA methylation is one of the earliest hallmarks of cancer. DNMT1 is responsible
for methylating newly replicated DNA, but the precise regulation of DNMT1 to ensure faithful …
for methylating newly replicated DNA, but the precise regulation of DNMT1 to ensure faithful …
Deep enzymology studies on DNA methyltransferases reveal novel connections between flanking sequences and enzyme activity
A Jeltsch, S Adam, M Dukatz, M Emperle… - Journal of molecular …, 2021 - Elsevier
DNA interacting enzymes recognize their target sequences embedded in variable flanking
sequence context. The influence of flanking sequences on enzymatic activities of DNA …
sequence context. The influence of flanking sequences on enzymatic activities of DNA …