There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …

Understanding human organ formation is a scientific challenge with far-reaching medical
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …

In primates, the amnion emerges through cavitation of the epiblast during implantation,
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Embryonic development is orchestrated by robust and complex regulatory mechanisms
acting at different scales of organization. In vivo studies are particularly challenging for …

Stem cell-based embryo models open an unprecedented avenue for modeling
embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in …

Embryoids and organoids hold great promise for human biology and medicine. Herein, we
discuss conceptual and technological frameworks useful for developing high-fidelity …

A fundamental question in developmental biology is how the early embryo establishes the
spatial coordinate system that is later important for the organization of the embryonic body …

The way in which interactions between mechanics and biochemistry lead to the emergence
of complex cell and tissue organization is an old question that has recently attracted …