[HTML][HTML] Early human embryonic development: Blastocyst formation to gastrulation
J Rossant, PPL Tam - Developmental cell, 2022 - cell.com
There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …
Stem-cell-based embryo models for fundamental research and translation
Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
Human neural tube morphogenesis in vitro by geometric constraints
Understanding human organ formation is a scientific challenge with far-reaching medical
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …
Amniogenesis occurs in two independent waves in primates
M Rostovskaya, S Andrews, W Reik, PJ Rugg-Gunn - Cell Stem Cell, 2022 - cell.com
In primates, the amnion emerges through cavitation of the epiblast during implantation,
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …
whereas in other species it does so later at gastrulation by the folding of the ectoderm. How …
Advancing models of neural development with biomaterials
Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …
Self-organization of stem cells into embryos: a window on early mammalian development
Embryonic development is orchestrated by robust and complex regulatory mechanisms
acting at different scales of organization. In vivo studies are particularly challenging for …
acting at different scales of organization. In vivo studies are particularly challenging for …
Opportunities and challenges with stem cell-based embryo models
J Rossant, PPL Tam - Stem Cell Reports, 2021 - cell.com
Stem cell-based embryo models open an unprecedented avenue for modeling
embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in …
embryogenesis, cell lineage differentiation, tissue morphogenesis, and organogenesis in …
Engineering multiscale structural orders for high-fidelity embryoids and organoids
Embryoids and organoids hold great promise for human biology and medicine. Herein, we
discuss conceptual and technological frameworks useful for developing high-fidelity …
discuss conceptual and technological frameworks useful for developing high-fidelity …
Axis specification in zebrafish is robust to cell mixing and reveals a regulation of pattern formation by morphogenesis
A fundamental question in developmental biology is how the early embryo establishes the
spatial coordinate system that is later important for the organization of the embryonic body …
spatial coordinate system that is later important for the organization of the embryonic body …
Roadmap for the multiscale coupling of biochemical and mechanical signals during development
The way in which interactions between mechanics and biochemistry lead to the emergence
of complex cell and tissue organization is an old question that has recently attracted …
of complex cell and tissue organization is an old question that has recently attracted …