Mutations in the gene encoding the inner nuclear membrane proteins lamins A and C
produce cardiac and skeletal muscle dysfunction referred to as Emery Dreifuss muscular …

A variety of studies that are currently underway may validate the fruit fly as an in vivo model
for analyzing genes involved in cardiac function. Many mutations in conserved genetic …

Humans sleep approximately a third of their lifetime. The observation that individuals with
either long or short sleep duration show associations with metabolic syndrome and …

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important
role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in …

ATP‐sensitive potassium channels (KATP) are widely distributed and present in a number of
tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by …

ATP-sensitive potassium (KATP) channels are evolutionarily conserved plasma-membrane
protein complexes, widely represented in tissue beds with high metabolic activity. There …

Bacillus anthracis edema toxin (ET), an adenylyl cyclase, is an important virulence factor that
contributes to anthrax disease. The role of ET in anthrax pathogenesis is, however, poorly …

ATP-sensitive K+ channels, termed KATP channels, provide a link between cellular
metabolism and membrane electrical activity in a variety of tissues. Channel isoforms have …

ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout
nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad …

Physiological and pathophysiological roles of KATP channels have been clarified recently in
genetically engineered mice. The Kir6. 2-containing KATP channels in pancreatic ß-cells …