Kir6. 1 and SUR2B in Cantú syndrome
C McClenaghan, CG Nichols - American Journal of …, 2022 - journals.physiology.org
Kir6. 1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a
wide range of tissues. Extensive study has implicated roles of these channel subunits in …
wide range of tissues. Extensive study has implicated roles of these channel subunits in …
Differential Structure of Atrial and Ventricular KATP Atrial KATP Channels Require SUR1
The isoform-specific structure of the ATP-sensitive potassium (KATP) channel endows it with
differential fundamental properties, including physiological activation and pharmacology …
differential fundamental properties, including physiological activation and pharmacology …
[HTML][HTML] A perfusion procedure for imaging of the mouse cerebral vasculature by X-ray micro-CT
Background Micro-CT is a novel X-ray imaging modality which can provide 3D high
resolution images of the vascular network filled with contrast agent. The cerebrovascular …
resolution images of the vascular network filled with contrast agent. The cerebrovascular …
KV7 potassium channels: a new therapeutic target in smooth muscle disorders
Potassium channels are key regulators of smooth muscle tone, with increases in activity
resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction …
resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction …
[HTML][HTML] Human KATP channelopathies: diseases of metabolic homeostasis
TM Olson, A Terzic - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
Assembly of an inward rectifier K+ channel pore (Kir6. 1/Kir6. 2) and an adenosine
triphosphate (ATP)-binding regulatory subunit (SUR1/SUR2A/SUR2B) forms ATP-sensitive …
triphosphate (ATP)-binding regulatory subunit (SUR1/SUR2A/SUR2B) forms ATP-sensitive …
[HTML][HTML] Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease …
F Maqoud, N Zizzo, M Attimonelli, A Tinelli… - Frontiers in …, 2023 - frontiersin.org
Background: ATP-sensitive-K+ channels (KATP) are involved in diseases, but their role in
cancer is poorly described. Pituitary macroadenoma has been observed in Cantu'syndrome …
cancer is poorly described. Pituitary macroadenoma has been observed in Cantu'syndrome …
[HTML][HTML] Physiological consequences of complex II inhibition for aging, disease, and the mKATP channel
AP Wojtovich, CO Smith, CM Haynes… - … et Biophysica Acta (BBA …, 2013 - Elsevier
In recent years, it has become apparent that there exist several roles for respiratory complex
II beyond metabolism. These include:(i) succinate signaling,(ii) reactive oxygen species …
II beyond metabolism. These include:(i) succinate signaling,(ii) reactive oxygen species …
[HTML][HTML] Coronary artery spasm-related heart failure syndrome: literature review
MJ Hung, CT Yeh, NG Kounis, I Koniari, P Hu… - International journal of …, 2023 - mdpi.com
Although heart failure (HF) is a clinical syndrome that becomes worse over time, certain
cases can be reversed with appropriate treatments. While coronary artery spasm (CAS) is …
cases can be reversed with appropriate treatments. While coronary artery spasm (CAS) is …
ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target
The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human
neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a …
neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a …
Role of potassium channels in coronary vasodilation
K+ channels in coronary arterial smooth muscle cells (CASMC) determine the resting
membrane potential (E m) and serve as targets of endogenous and therapeutic vasodilators …
membrane potential (E m) and serve as targets of endogenous and therapeutic vasodilators …