K+ channels in coronary arterial smooth muscle cells (CASMC) determine the resting
membrane potential (E m) and serve as targets of endogenous and therapeutic vasodilators …

ATP-sensitive potassium channels (KATP) regulate a range of biological activities by
coupling membrane excitability to the cellular metabolic state. In particular, it has been …

Insulin secretagogues (sulfonylureas and glinides) increase insulin secretion by closing the
ATP-sensitive K+ channel (KATP channel) in the pancreatic β-cell membrane. KATP …

ATP-sensitive K+ channels (KATP channels) are present in various tissues, including
pancreatic β-cells, heart, skeletal muscles, vascular smooth muscles, and brain. KATP …

Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in
ABCC9 and KCNJ8, which encode the SUR2 and Kir6. 1 subunits, respectively, of vascular …

Creatine is an organic compound, consumed exogenously in the diet and synthesized
endogenously via an intricate inter-organ process. Functioning in conjunction with creatine …

ATP-sensitive potassium (K ATP) channels are widely expressed in the cardiovascular
system, where they regulate a range of biological activities by linking cellular metabolism …

Background Electrophysiological data suggest that cardiac K ATP channels consist of Kir6. 2
and SUR2A subunits, but the distribution of these (and other K ATP channel subunits) is …

Alternative splicing allows multiple mRNAs to be generated from a single gene, which in turn
can be translated into a group of diverse proteins with different roles and structures. The …

Scutellaria baicalensis Georgi is an extensively used medicinal herb for the treatment of
hypertension in traditional Chinese medicine. Baicalin is the most abundant flavone …