Coronary artery spasm (CAS) is a reversible phenomenon caused by spontaneous
excessive vascular smooth muscle contractility and vascular wall hypertonicity, which results …

Arterial ATP-sensitive K+ (KATP) channels are critical regulators of vascular tone, forming a
focal point for signaling by many vasoactive transmitters that alter smooth muscle …

Background KATP channels, assembled from pore‐forming (Kir6. 1 or Kir6. 2) and
regulatory (SUR 1 or SUR 2) subunits, link metabolism to excitability. Loss of Kir6. 2 results …

Ischemia with non-obstructive coronary arteries (INOCA) has gained increasing attention
due to its high prevalence, atypical clinical presentations, difficult diagnostic procedures and …

The activation of ATP-sensitive K+ channels by protein kinase A in vascular smooth muscle
is an important component of the action of vasodilators. In this study, we examine the …

ABCC9‐related intellectual disability and myopathy syndrome (AIMS) arises from loss‐of‐
function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP …

Hydrogen sulfide (H2S) is a gaseous signaling molecule that appears to contribute to the
regulation of vascular tone and blood pressure. Multiple potential mechanisms of vascular …

Abstract The University Group Diabetes Program (UGDP), launched in 1960, was an early
placebo-controlled, multi-center clinical trial devised to determine which, if any, of the …

Air pollution is positively associated with increased daily incidence of myocardial infarction
and cardiovascular mortality. We hypothesize that air pollutants, primarily vapor phase …

Functional ATP-sensitive potassium (KATP) channels can be reconstituted by expression of
various combinations of different pore-forming subunits (Kir6. 1 and Kir6. 2) and sulfonylurea …