[HTML][HTML] Cellular remodeling in heart failure disrupts KATP channel‐dependent stress tolerance
DM Hodgson, LV Zingman, GC Kane… - The EMBO …, 2003 - embopress.org
Abstract ATP‐sensitive potassium (K ATP) channels are required for maintenance of
homeostasis during the metabolically demanding adaptive response to stress. However, in …
homeostasis during the metabolically demanding adaptive response to stress. However, in …
Spontaneous Coronary Vasospasm in KATP Mutant Mice Arises From a Smooth Muscle–Extrinsic Process
R Kakkar, B Ye, DA Stoller, M Smelley, NQ Shi… - Circulation …, 2006 - Am Heart Assoc
In the vasculature, ATP-sensitive potassium channels (KATP) channels regulate vascular
tone. Mice with targeted gene disruptions of KATP subunits expressed in vascular smooth …
tone. Mice with targeted gene disruptions of KATP subunits expressed in vascular smooth …
Glucagon-like peptide-1 analog liraglutide attenuates pressure-overload induced cardiac hypertrophy and apoptosis through activating ATP sensitive potassium …
XJ Bai, JT Hao, RH Zheng, CP Yan, J Wang… - … drugs and therapy, 2021 - Springer
Purpose This study aimed to investigate whether inhibition of glucagon-like peptide-1 (GLP-
1) on pressure overload induced cardiac hypertrophy and apoptosis is related to activation …
1) on pressure overload induced cardiac hypertrophy and apoptosis is related to activation …
ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9
MF Smeland, C McClenaghan, HI Roessler… - Nature …, 2019 - nature.com
Mutations in genes encoding KATP channel subunits have been reported for pancreatic
disorders and Cantú syndrome. Here, we report a syndrome in six patients from two families …
disorders and Cantú syndrome. Here, we report a syndrome in six patients from two families …
Exchange protein activated by cAMP (Epac) mediates cAMP‐dependent but protein kinase A‐insensitive modulation of vascular ATP‐sensitive potassium channels
GI Purves, T Kamishima, LM Davies… - The Journal of …, 2009 - Wiley Online Library
Exchange proteins directly activated by cyclic AMP (Epacs or cAMP‐GEF) represent a family
of novel cAMP‐binding effector proteins. The identification of Epacs and the recent …
of novel cAMP‐binding effector proteins. The identification of Epacs and the recent …
PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors
ATP-sensitive K+ (KATP) channels are activated by several vasodilating hormones and
neurotransmitters through the PKA pathway. Here, we show that phosphorylation at Ser1387 …
neurotransmitters through the PKA pathway. Here, we show that phosphorylation at Ser1387 …
KATP channel: relation with cell metabolism and role in the cardiovascular system
ML Zhuo, Y Huang, DP Liu, CC Liang - The international journal of …, 2005 - Elsevier
ATP-sensitive potassium channel (KATP) is one kind of inwardly rectifying channel
composed of two kinds of subunits: the pore forming subunits and the regulatory subunits …
composed of two kinds of subunits: the pore forming subunits and the regulatory subunits …
Pulmonary hypertension and ATP-sensitive potassium channels: paradigms and paradoxes
C McClenaghan, KV Woo, CG Nichols - Hypertension, 2019 - Am Heart Assoc
ATP-sensitive potassium (KATP) channels represent a subfamily of potassium channels that
link metabolic state to electrical activity in tissues throughout the body. KATP channel activity …
link metabolic state to electrical activity in tissues throughout the body. KATP channel activity …
Gene knockout of the KCNJ8‐encoded Kir6.1 KATP channel imparts fatal susceptibility to endotoxemia
GC Kane, CF Lam, F O'Cochlain… - The FASEB …, 2006 - Wiley Online Library
Sepsis, the systemic inflammatory response to infection, imposes a high demand for bodily
adaptation, with the cardiovascular response a key determinant of outcome. The …
adaptation, with the cardiovascular response a key determinant of outcome. The …
Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease …
F Maqoud, N Zizzo, M Attimonelli, A Tinelli… - Frontiers in …, 2023 - frontiersin.org
Background: ATP-sensitive-K+ channels (KATP) are involved in diseases, but their role in
cancer is poorly described. Pituitary macroadenoma has been observed in Cantu'syndrome …
cancer is poorly described. Pituitary macroadenoma has been observed in Cantu'syndrome …