Rationale: Ventricular fibrillation (VF) leads to global ischemia. The modulation of ischemia-
dependent pathways may alter the electrophysiological evolution of VF. Objective: We …

The ATP-sensitive K+ (KATP) channels are hetero-octameric protein complexes comprising
4 pore-forming (Kir6. x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits …

Aims/hypothesis Sulfonylureas and glinides close beta cell ATP-sensitive K+(K ATP)
channels to increase insulin release; the concomitant closure of cardiovascular K ATP …

Highlights•Mutations in the TRPM4 gene are associated with dysfunctions in the cardiac
conduction system.•At the molecular level mutations in TRPM4 lead to gain-of-channel …

Specific homeostatic mechanisms confer stability in innate immune responses, preventing
injury or death from infection. Here we identify, from a screen of N-ethyl-N-nitrosourea …

Mutations in ABCC8 have been identified in pulmonary arterial hypertension (PAH). ABCC8
encodes SUR1, a regulatory subunit of the ATP-sensitive potassium channel Kir6. 2 …

Different types of ATP-sensitive K+ (KATP) channels have been identified in cardiomyocytes,
vascular smooth muscle cells, pancreatic β-cells, neurons and mitochondria. Years before …

Cardiac ATP-sensitive K+ (KATP) channels are formed by Kir6. 2 and SUR2A subunits. We
produced transgenic mice that express dominant negative Kir6. x pore-forming subunits …

Under physiologic conditions, epicardial arteries contribute minimally to coronary vascular
resistance. However, in the presence of endothelial dysfunction, stimuli that normally …

Consistent left–right asymmetry requires specific ion currents. We characterize a novel
laterality determinant in Xenopus laevis: the ATP-sensitive K+-channel (KATP). Expression …