Aims Membrane potential is a key determinant of vascular tone and many vasodilators act
through the modulation of ion channel currents [eg the ATP-sensitive potassium channel …

Abstract ATP-sensitive potassium (K ATP) channels are widely distributed in vasculatures,
and play an important role in the vascular tone regulation. The K ATP channels consist of 4 …

Vascular ATP-sensitive K+ (KATP) channels are critical regulators of arterial tone and, thus,
blood flow in response to local metabolic needs. They are important targets for clinically …

Sepsis is a severe medical condition causing a large number of deaths worldwide. Recent
studies indicate that the septic susceptibility is attributable to the vascular ATP-sensitive …

Key points• Essential hypertension involves an electrical remodelling of vascular smooth
muscle cells (VSMCs), particularly relevant for K+ channels, as key determinants of resting …

ATP-sensitive potassium (KATP) channels play fundamental roles in the regulation of
endocrine, neural and cardiovascular function. Small-molecule inhibitors (eg, sulfonylurea …

ABC transporters are a large family of membrane proteins that transport chemically diverse
substrates across the cell membrane. Disruption of transport mechanisms mediated by ABC …

Adenosine triphosphate-binding cassette (ABC) transporters are involved in energy-
dependent transport of substrates across biological membranes. We hypothesized that their …

ATP‐sensitive potassium channels (KATP channels) of arterial smooth muscle are important
regulators of arterial tone, and hence blood flow, in response to vasoactive transmitters …

Background Alterations in coronary vasomotor tone may participate in the pathogenesis of
acute myocardial infarction (AMI). Vascular ATP-sensitive K+(K ATP) channels, formed by …