A healthy heart adapts to changes in nutrient availability and energy demands. In metabolic
diseases like type 2 diabetes (T2D), increased reliance on fatty acids for energy production …

In human metabolism, pyruvate dehydrogenase complex (PDC) is one of the most intricate
and large multimeric protein systems representing a central hub for cellular homeostasis …

Glucose metabolism comprises numerous amphibolic metabolites that provide precursors
for not only the synthesis of cellular building blocks but also for ATP production. In this study …

Second messenger cyclic adenosine monophosphate (cAMP) has been found to regulate
multiple mitochondrial functions, including respiration, dynamics, reactive oxygen species …

In diseased states, the heart can shift to use different carbon substrates, measured through
changes in uptake of metabolites by imaging methods or blood metabolomics. However, it is …

Introduction and objectives Mitochondrial pyruvate carrier (MPC) mediates the entry of
pyruvate into mitochondria, determining whether pyruvate is incorporated into the Krebs …

Pyruvate is an essential metabolite produced by glycolysis in the cytosol and must be
transported across the inner mitochondrial membrane into the mitochondrial matrix, where it …

In this study, we observed worsening metabolic crosstalk in mouse models with concomitant
metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and …

Although metabolic remodeling during cardiovascular diseases has been well-recognized
for decades, the recent development of analytical platforms and mathematical tools has …

Abstract Elevated intracellular Na (Na i) and metabolic impairment are interrelated
pathophysiological features of the failing heart (HF). There have been a number of studies …