Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we
show that Mitochondrial Fission Process 1 (MTFP1) is essential for cardiac structure and …

Malate oxidation by plant mitochondria enables the generation of both oxaloacetate (OAA)
and pyruvate for tricarboxylic acid (TCA) cycle function, potentially eliminating the need for …

The versatile intracellular adaptor protein Tumor necrosis factor receptor (TNFR) associated
factor 3 (TRAF3) plays an important role in T cell biology. Mice with T cell-specific TRAF3 …

The cardiometabolic disease represents a collection of common and interrelated conditions
that accelerate the risk of developing cardiovascular diseases. Of importance, metabolic …

While the heart is a 'metabolic omnivore', the predominant sources of energy production are
fatty acid and glucose/lactate catabolism (Stanley et al. 2005). Cardiomyocytes can also …

Heart failure is a condition whereby the weakened cardiac muscle can no longer pump
blood to the rest of the body, resulting in decreased quality of life. Despite the severity of this …

Ketogenic diets are characterized by a reduction in carbohydrates and a relative increase in
the proportions of proteins and fats. The first goal of the research was to identify exactly the …

Genetic variation in genes regulating metabolism may be advantageous in some settings
but not others. The non-failing adult heart relies heavily on fatty acids as a fuel substrate and …

Regular aerobic exercise promotes physiological cardiac growth, which is an adaptive
response thought to enable the heart to meet higher physical demands. Cardiac growth …