Information on drug absorption and disposition in infants and children has increased
considerably over the past 2 decades. However, the impact of specific age-related effects on …

Routine assessment and management of neonatal pain has evolved to become an
important therapeutic goal in the twenty-first century. During the twentieth century, however …

A number of anatomical and physiological factors determine the pharmacokinetic profile of a
drug. Differences in physiology in paediatric populations compared with adults can influence …

Many physiologic differences between children and adults may result in age-related
changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and …

Background Prediction of the exposure of neonates, infants and children to xenobiotics is
likely to be more successful using physiologically based pharmacokinetic models than …

The approach to paediatric drug dosing needs to be based on the physiological
characteristics of the child and the pharmacokinetic parameters of the drug. This review …

Many drugs prescribed to children are drug transporter substrates. Drug transporters are
membrane-bound proteins that mediate the cellular uptake or efflux of drugs and are …

The accurate prediction of pharmacokinetics (PK) is fundamental to underwriting safety and
efficacy in pediatric clinical trials; age‐dependent PK may be observed with pediatrics …

The complex process of oral drug absorption is influenced by a host of drug and formulation
properties as well as their interaction with the gastrointestinal environment in terms of drug …

Physiological functions of the two extreme ends of the age spectrum, children (< 18 y old)
and older adults (aged 65 y and over), differ from healthy young adults. This consequently …